seriously profitable? VIVO went from 13 to 0.88, INN from $16 to $1, SPK from 13 down death to 0.05, the list continues...You have to make hundred % just to make even. What's staking/MN for?

Then just wait for the price to drop and grab yourself a nice and cheap MN. Since the initial drop and after people start buying the coins and the price goes a bit up, it should be stable. At least those are my observations so far, make your own researches.
Otherwise - I am running a PROTON MN and also thinking of getting myself a QBIC MN also.

Another question for those with experience. Can you sell the coins used as colateral after the masternode is confirmed? Or do you have to keep them in the wallet?

Thanks for the info and clarification @ronnylov. Will check the coins you mentioned. I also think its good time to buy some MN. So to give info back, the profitable I found that also have a setup guide:

- Galactrum
- NYXCoin
- Polis
- Pirl (very expensive)
- ApollonCoin
- MagnetWork
- SagaCoin
- ZacaCoin

Did not check the background yet. May be all shitcoins. But they are all quite profitable atm and have a guide to setup the MN. Guide is important IMO because without it you can fail at setting the MN.

All in all I run about 20 masternodes for ~15 various altcoins.Bought/mined them all at the very start when returns were max (and ROI min.), months later they still give about 75-200% per annum.

I agree. A lot of MN looks the same. We'll end up with a lot of coins with ZERO value.

How do you run multiple MN for the same coin?

Just have them set up in different addresses/VPS.  I ran 4 XIOS MN before the coin forked.  I think I hit the diamond in the rough at the right time and got it when the coin was in the 40 cent range and sold 80% of everything when it peaked around $4.  I'm hoping when the fork is complete and the XUEZ coin is launched that the Mastnode program keeps trending upward.  I had a great experience and got extremely lucky on timing but with the right coin and getting in at the right time staking and running a masternode can be profitable.  Unfortunately, most of the timing was getting in before the run-up of every coin.  Need to pick and choose now, be patient and only get involved in a project you plan to hold and believe in.

VIVO, INN, SMART, ZEN, BWK, FOLM, ALQO, MUN, DESIRE, PURE, FOLM, IFX and few others. So far only MUN has really let me down.