I agree with you. This is going to be the most exciting match of this round of the Europa League. And I would also expect Leipzig's victory. Because their 4-1 win against a team like Dortmund was extraordinary. But I wouldn't call Atalanta a weak team. Atalanta is a very strong team but they are a bit off form now. And they are not playing well on a regular basis. This is why I will keep the Leipzig team ahead.

Atalanta were out of Champions League because Ronaldo saved Manchester United. They are the most consistently impressive club in Serie A last three seasons. This season is a difficult one for Atalanta because they are facing with a first one will not complete in top 4. If they can not complete it in top 4, many star players were grown in Atalanta will leave Bergamo and find other bigger clubs.

So a trophy in Europa League might be one of important reasons to convince their star players to stay in Bergamo. Football is not a math so Atalanta might suddenly come back to their best and beat Leipzig.

This RB leipzig vs Atalanta match will be an interesting match considering they are the dark horse team in the European League this season where the performance of both in the domestic league is slightly inverse where in the match they played where RB leipzig managed to beat Borussia Dortmund 1-4 meanwhile Atalanta had to lose to their visitors Napoli 1-3, of course this will be a motivation for both of them but has the advantage of being the host first, of course the German team wants to score a lot of goals to keep their hopes of qualifying for the semifinals when the two meet in Italy

Currently, their performance in their respective domestic leagues is quite the opposite, I think.
Leipzig are currently in quite high confidence as they are in good form in the Bundesliga but in contrast to Atalanta who are still not doing very well for them in Serie A.
Even though the Europa League has nothing to do with this, the results in their respective leagues will definitely affect their performance, I think.
Well at the moment even though at first I was at Atalanta but maybe in this match Leipzig will be quite seeded in my opinion

Barcelona is ready to go as far as possible in the Europa League competition.  For them, it is not something impossible.

 Since the arrival of Xavi and a number of new ammunition, Barcelona, ​​which had slumped at the beginning of the season, has now returned to being a scary team.

 Barcelona is unbeaten in the last 13 matches in all competitions.  They are also considered very likely to overthrow Frankfurt at their own home.

Lyon indeed unbeatable since group stage and maybe in this match they are the favourite but do not forget West Ham has successfully to beat defending champion Sevilla and i think every West Ham opponents should not be underestimate them anymore because they can playing unpredictable so in my view West Ham could be tough opponent for Lyon and won't be easy to defeated especially playing at home

Lyon's performance is indeed inconsistent in Ligue 1, but if we look at Lyon's performance in the Europa League it is very different. Lyon until now
in the Europa League has not been defeated, so quite a lot of people predict Lyon will beat West Ham. But I have a different prediction, because I see
West Ham's chances of winning are much higher. In addition to West Ham managed to get rid of Sevilla, which is one of the strong teams in La Liga,
West Ham also like Lyon played very well since the group stage in the Europa League. So actually their strength is not much different, but because
it is a typical Premier League team, West Ham will play more aggressively if they play at home. It looks like Lyon will find it difficult to deal with attacks
from West Ham players, unlike Lyon, West Ham's performances are also quite good in the Premier League. Even West Ham this season still has
the opportunity to enter the top 4 in the Premier League, therefore I predict West Ham will beat Lyon in the first leg.

You miss predicting with Frankfurt vs Barcelona match and I think this match looks interested with many predicting favorite Barcelona as the winner, but I don't see have chance because Frankfurt play as home and have a lot off motivation how to win on first leg UEFA Europe League. I think Frankfurt have great fans and give pressure for Barcelona player and I think although ball possession winning by Barcelona not happening with match result, I think Frankfurt vs Barcelona between draw or Frankfurt as the winner tonight.

West Ham have improved a lot from the first leg, even they're not have high ball possession but they can shoot more than Sevilla. It's was unpredictable since many people speculate Sevilla would win because their first leg they have won. Lyon is really hard to beat, Karl Toko Ekambi is a good shooter rather than Benrahma IMO. I'd say West Ham is inconsistent with their performance, they're sometime good but sometime they're not good too.

Lyon and West Ham are almost the same quality team. Both teams are quite irregular. So it is not clear which team will win today's match. Often these teams show excellent performance and even win against strong opponents. As a home team, West Ham's players will be a bit more confident. And this confidence will probably help them to perform better. West Ham's performance against Sevilla was good. If they can do the same today, they are more likely to win.