Lack of understanding and knowledge about Bitcoin will certainly make someone worry when investing in Bitcoin and this certainly will not make them invest in Bitcoin, but for some people who invest in Bitcoin of course they will hope to be able to make a profit from the investment they make and it is very unlikely that someone who invests does not hope to be able to make a profit.
Honestly, when someone lacks good knowledge about Bitcoin, their mind will never be at rest because they will always be thinking about whether they will be able to make a profit from their Bitcoin investment or not. Especially given the volatile nature of Bitcoin, as the price changes, particularly when the Bitcoin market is dipping. If someone does not have proper knowledge of Bitcoin and how its market works, they will always be panicking as the price keeps changing. This is what leads some people to end up selling their Bitcoin when they don't have confidence over time the price of Bitcoin will recover.
Of course we have to focus on what we do in investing without having to care about what other people do and for those who are still hesitant until now of course they will regret it when other people make a profit and they have missed the opportunity because of the hesitation they have to invest in Bitcoin.
The reason why many people never invested in Bitcoin, or sell their Bitcoin along the way, is because they always give a listening ear to some people who don't understand much about Bitcoin. I will never say that someone should not listen to advice from others, but as someone is listening to advice, they should also try to do their own research. With that, one can gain their own confidence and know what they are doing is right. As you have said, honestly, many people are now regretting why, when they were aware of Bitcoin back in the day, they refused to invest.