Yes i think this topic of lost bitcoins is quite interesting and closely tied to the fundamentals of bitcoin. The total supply of bitcoin is fixed at 21 million doller. And  this will never change. However bitcoins that are lost due to inaccessible wallets or forgotten seed phrases are effectively removed from circulation forever. Research estimates that around 4 million bitcoins are already lost. and this number is likely to increase over time.This means the actual circulating supply is less than 21 million doller  which strengthens bitcoin scarcity and value proposition. Lost bitcoins cannot be recovered or recirculated by any centralized authority they remain permanently locked on the blockchain. This ensures the decentralized and predictable nature of bitcoin remains intaction. i think in the long term, the loss of bitcoins increases scarcity which could influence price if demand remains steady or grows. Simply put what is lost is lost forever, and this is an integral part of bitcoin’s design and scarcity model.

Nothing is sad about it, it is a consequence of your own actions. Don't want consequences? Then be more responsible in your behavior. Anyhow, it is the utilitarian view that this is a good cause. So many people benefit from one person's mistakes or stupidity. Thereby the benefits definitely outweigh the negatives.

Many of the losses are not sad, they are just hindsight bias situations. What is worse, losing the coin or spending it on something useless in the early days? For me it is not much different. The people that have managed to keep their coin secure all this time are the ones that probably deserve it as they spent sufficient time into ensuring this safety.

I found this interesting. In fact, it got me thinking. When your coins are backed up and your seed phrase or private keys are placed in three locations, don't you think the possibility of some unauthorized person getting hold of the private key increases? I don't know who else does this, but unlike placing your coins' private key in a safe deposit or something similar, placing them in three different places could make them fall into the wrong hands, don't you think so?