The only time I am more concerned is when bitcoin mining ends in 2140 and the miners are left with only fees as incentives, this would be hard, but I want to believe that Satoshi has planned for those times from the very beginning. As long as new bitcoin is still mined, no matter the fraction, it would suit well since if bitcoin price continues to go up and by then, bitcoin price is up to $300k, then the block reward of 0.396025 becomes $118,807.5 per block which is still adding up.
It will be an interesting time because I dont see the fees actually been able to sustain the miners then because a much higher fee will only discourage transactions through the bitcoin network, Bitcoin will have its volatility reduced then but will be very well over the $300k region in my opinion, from now to 2140 is a whole 115 years apart and with the history of how bitcoin is pumping we could even be around $1m per bitcoin then 1sats/vbyte wouldnt still be much if it is the fee then.
One of my major guesses for this period is that some miners might drop out if mining isnt profitable again and could possibly reduce the hashrate power if I am not mistaken, but lets not even think about then because it is seriously a long time from now and most of us wouldnt be here then