What is your definition of "truly mainstream" ?
If 1% of the world uses Bitcoin for 1% of their transactions, then I'd still consider it a huge success. I think there's a good chance that happens, but that doesn't fit my definition of 'mainstream.'
I think there is small possibility Bitcoin proper is used by a majority of people in some country somewhere in the world use it at least once a week to pay for things. I'd consider that mainstream success.
I think there's a tiny possibility Bitcoin will eventually become as popular as the dollar.
But I'm not very good at predicting the future, so you might want to consult you local fortune teller.
Let's consider what Gavin is saying here for a moment. 1% of world txns is pretty enormous. Let's say there are only two future possibilities:
1) Gavin's dream comes true (Bitcoin accounts for 1% of world txns)
2) Bitcoin fails and value decreases to 0.
The current bitcoin price indicates a guess about the probability of the two scenarios. What is this guess? Let's refer to a back-of-the-envelope calculation
Japan accounts for about 7% of world economic activity, that is 7% of world txns. The Japanese narrowly-defined money supply (M1) was about 9 trillion USD in 2009. Therefore we might expect bitcoin market cap under possibility (1) to be about 1/7 of this. That is under scenario 1, bitcoin market cap should grow to about 1.25 trillion USD. Dividing this by the 21 million bitcoins in existence, each bitcoin should be worth about 60,000 USD.
Right now bitcoin sells for about 5 USD. Let's consider the two future scenarios again.
1) Each bitcion worth US$60k each in future
2) Each bitcion worth US$0 in future.
What probability is the market putting on scenario 1? If bitcoin has a 1 in 12000 chance of growing in value to 60k and a 11999 in 12000 chance of falling in value to 0, then a price of 5 USD implies a fair gamble. Thus the implied probability is 1 in 12000.
I am not opposed to putting some money down on a 1 in 12000 chance. It is reasonable to gamble away small amounts. However, I am opposed to describing this as a "good chance." Without any further details, your audience will likely get confused about their odds.
Note: it's worth noting that introducing additional, intermediate scenarios will decrease the chance below 1 in 12000. We can think of 1 in 12000 as an upper bound on the market-implied probability that Gavin's dream will come to pass.