A massive price collapse paired with a massive miner dropout has nearly destroyed Namecoin once.
That is harder to happen with Bitcoin but it's also that much harder to recover from since there are no alternatives and simply limping to the next difficulty adjustment won't help. Namecoin went to merged mining as a solution, so if that happens to Bitcoin it has to go on over several difficulty adjustments, which may never happen if miner dropout continues.
In that case the Blockchain grinds to a halt, with months between blocks until nobody even bothers to store the Blockchain.
Most people here will claim this can never happen.
