what you mine with is irrelevant - it doesn't matter if you have 10 mh/s or 1000 mh/s choosing the wrong coin hurts and unless you've developed what we've developed and it's almost impossible to compile enough data constantly and present it in an intelligible format to make sense of it all.
However using a Titan does present you with challenges because it limits your coin choices to about 10 to 15 coins because of their daily yields.
people with multiple smaller miners have the advantage "quite often of spreading their hashing power around" o course you have the advantage in loer power consumption per MH/s but that can easily be squandered by choosing the wrong coin.
as a pool owner - I see it all - I saw a person the other day with 150 MH/s mining Goldcoin - which was 'insane" if you are mining for profitability - there were at least 14 other coins that would have given this person 4 to 5 times the daily yield they he was getting on Goldcoin -but hey - it's his machine and he can do what he wants - He got the SmarterHash mailer and decided he knew more - too bad that in seven says of mining Goldcoin he lost about $45 in potential income - but on the bright side it was one less person I had to compete with for the more profitable coins, right?
large boxes like your Titan can be more challenging sometimes.
For instance I have two MAT machines (256 MH/s), one A2 and three zeus machines that are 30, 40 and 60 mh/s
lately I have found it's been more profitable for me to sick my 256 MH/s machines on different coins and take my other four machines and allocate about 100mh/s to another two coins in order to optimize my daily returns.
but don't take my word for it. -see for yourself in the Video I put together - you'll want to maximize the screen - it's about 30 minutes in length an thanks for asking and best of luck to you... ps - all of my pools have high difficulty ports for fast machines like yours.
https://www.youtube.com/watch?v=O7EMYchCUhUthanks and I hope this information has been helpful to you...