Just wondering how wise it would be to run a masternode from a secondary computer on a home network?
I guess that depends if your a business or a hobbyist ?

Again, a secondary static IP address, encrypted DNS, VPN (optional) and I reckon your set - If you decide that running a Darkcoin master node is right for you as an individual.
- People get paranoid about running Tor relays, for example, I've run one from my 'home' network 24/7 for around 2 years without having any issues whatsoever.
The thing about 'anonymity' projects is that any log keeping actually makes you more liable to revealing those logs. Not keeping any logs and having no knowledge of any processed transactions or data is probably beneficial, perhaps over storage of the Bitcoin blockchain, for example. This is obviously dependent on your jurisdiction.
I'll be running Peerblock and/or Peer Guardian with some free and paid lists from iblocklist.com - in an effort to prevent my relay node from being used by any 'bad' actors.
At last you can present that you are running your node in the interest of internet privacy and anonymity, as oppose to supporting any criminal activity and in fact put measures in place to prevent such activities, where possible.
Darkcoin is potentially the 'anonymous' eCash that Bitcoin claimed to be. In fact, using cash is still potentially more 'anonymous' than using Darkcoin!