Big leagues? Not quite yet.
To continue with baseball terms, I'd call MintPal/Cryptsy the college level with a mix of divisions. I'd call Bitfinex triple-A. Going public with a tracking/trust etf would be the big leagues, IMO.
At Bitfinex there will be large 'scouts' watching DRK closely to eventually see if it warrants an ETF ala Bitcoin.
JL
Please no ETFs, we don't need it. If you want to participate then buy the damn coin. Why do you need to create derivatives? It will just take away the actual market from the coin? Who is going to audit the ETFs to see if they actually hold the amount of coins they say they have? We have enough issues with that in the gold and silver markets. Please no ETFs.