Derivatives are about to be unleashed on Bitcoin, so the problems gold has will become Bitcoin's. Yes it's becoming a big boy's game, and it'll be manipulated all the same.
The only difference is that investment must be saturated before it's fleeced. Bitcoin will have to go up a very long way until it's no longer the golden child of institutional giants.
I don't think the same games can be played as they are with PMs. Comex gold derivatives take advantage of the difficulty and expense of opting for physical delivery of gold contracts. There is no case to be made for the situation being the same for Bitcoin, and so if the Wall Street exchanges refuse or stall withdrawals, then they'll get tarred with the Gox moniker. Not to say that this won't happen, but I think the problems with Bitcoinica, Mt. Gox and Vicurex will be way too fresh in people's minds to permit recklessly large deposits on an exchange run in Wall Street (of all places, at this point in the history of that institution's reputation). Watch closely the language that gets used to describe their processes, if "withdrawal", "deposit" and "balance" are passed over for some other euphemisms, tread carefully, and deride loudly if necessary.
Any exchange that joins in with Second Market's 'hub and spoke' arrangement can expect to see some very guarded use of their deposit facilities. Sounds like a situation where mutual finger-pointing will replace meaningful responsibility if there was ever an issue.