They run with BFGminer also. The earliest I've used is 4.5.0.
People were having so many problems using bfgminer on the original that I had to stop recommending it in this case. I'm not sure if it was continual user error or what, but you can have a look through the old thread.
It's been rocking solid for me for over a month on a mixed batch of the new R-boxes as well as the older ones. No problems at all.

I have them clocked back some because the old r-boxes don't like the higher speeds.